In the January 2011 edition of Nature Reviews Drug Discovery Dr. Clarkson in her paper Stroke: Removing restraints on recovery discusses that GABA acts as an inhibitor of neural excitability and therefore removing this inhibitor post stroke may result in an improvement in locomotor function.
Recovery after stroke involves remapping of the neuronal circuitry in the regions adjacent to the site of injury — the peri-infarct zone — (neural plasticity) but so far there are no pharmacological therapies that can promote this. Now, Clarkson et al. show that inhibiting tonic GABA (gamma-aminobutyric acid)-ergic signalling days after a stroke can improve locomotor function.
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